From his very first contact with native people, Columbus had their domination in mind. For example, on October 14, 1492, Columbus wrote in his journal, "with fifty men they can all be subjugated and made to do what is required of them."  These were not mere words: after his second voyage, Columbus sent back a consignment of natives to be sold as slaves. 
Columbus, in need of a cargo other than gold and spices to ship to Spain, decided to send the Taino slaves as a show of the wealth available in the New World. He loaded the “best men and women” onto ships and sent them off to Europe, thus beginning the widespread enslavement of the native peoples.
His marauding band hunted Indians for sport and profit – beating, raping, torturing, killing, and then using the Indian bodies as food for their hunting dogs. Within four years of Columbus' arrival on Hispaniola, his men had killed or exported one-third of the original Indian population of 300,000.
They forced their way into native settlements, slaughtering everyone they found there, including small children, old men, pregnant women, and even women who had just given birth. They hacked them to pieces, slicing open their bellies with their swords as though they were so many sheep herded into a pen. They even laid wagers on whether they could manage to slice a man in two at a stroke, or cut an individual's head from his body, or disembowel him with a single blow of their axes. They grabbed suckling infants by the feet and, ripping them from their mothers' breasts, dashed them headlong against the rocks.
After exploring hundreds of islands but failing to find much gold, Columbus returned to Spain in 1496. He kidnapped some 500 natives to serve as slaves in the Old World, and half of them died en route.
In retrospect, if he had instead landed in a non-pacifist country, such as that of the Iroquois or Maya, history would have turned out differently. Their Warriors would have fought back ferociously, very probably ending his voyage on the American side of the Atlantic. If this had happened, and no Europeans had appeared for another century, population growth and technology development would have reduced the possibility of European colonization considerably. However, history turned out the way it did and no amount of fantasizing can change that.
Setting up shop on the large island he called Espa–ola (today Haiti and the Dominican Republic), he promptly instituted policies of slavery (encomiendo) and systematic extermination against the native Taino population.